Overview

CD3 MicroBeads were developed for positive selection or depletion of CD3+ T cells from peripheral blood, bronchial lavage, cell culture, or various tissues such as lymphoid, nasal, and tumor tissue.

 

Detailed product information

Background information

CD3 is expressed on all T cells and CD56+ NKT cells, and is associated with the T cell receptor. 70–80% of human peripheral blood lymphocytes and 65–85% of thymocytes are CD3+. The epitope recognized by CD3 MicroBeads is located on the CD3ε chain.

 

Downstream applications

T cells isolated by MACS® Technology have been used for various studies, e.g., on T cell cytotoxicity, T cell activation1, HIV infectivity2, signal transduction, and surface marker expression.

 

Columns

For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.